Figure 5.

GRHL2 down-regulates the expression of RhoG via binding its promoter. A. Schematic illustration of cloned fragment of the human RhoG promoter. The promoter region was predicted as three fragments (promoters 1-3). B. Transcriptional activity of GRHL2 on three RhoG promoter fragments, as indicated in H1299 cells. The luciferase activities of the promoter constructs were measured after normalization to Renilla luciferase activity. Data represent the average of three independent experiments (mean ± SD). *p<0.05, **p<0.01 vs. control siRNA.