Table 1.
UVA1 phototherapy for Localized scleroderma
| Scleroderma type | No. of patients | Treatment regimen | Dose per treatment (J/cm2) | No. of irradiations | Outcome | Referemce/first author |
|---|---|---|---|---|---|---|
| Severe LS | 10 | 4 s/w for 6 w | 20 | 24 | In all patients sclerosis regressed greatly after fewer than 15 treatment sessions. After 24 treatments, more than 80% of the lesions were completely cleared. | [8]/Martina Kerscher |
| Plaque, linear or deep morphea | 20 | 4 s/w for 6 w, further 1 s/w for 6 w | 20 | 30 | After 24 treatments,clearance of > 80% of lesions in 18 of 20 patients. 2 patients with SC morphea did not improve. | [9]/Martina Kerscher |
| Plaque or linear morphea | 7 | 3 s/w for 10 w | 30 | 30 | All patients showed significant decrease in induration of skin. In 1 patient, reduced joint mobility of elbow was restored to almost normal levels. | [10] Nydia R. Camacho |
| Severe plaque type morphea in different stages, 1 with overlying LSA | 3 | 4 s/w for 6 w, further 1 s/w for 6 w | 20 | 30 | After less than 15 sessions, clinical palpation for tethering or thickening of the skin revealed remarkable softening of sclerotic lesions. In morphea with overlying LSA the elastic fibers did not completely return to the superficial papillary dermis despite the clinical clearance. | [11]/Claus J. Gruss |
| LS | 8 | 4 s/w for 5 w | 48 | 20 | Treated skin showed a significantly increased elasticity at weeks 3, 5 and 7 when compared to control skin. No patients showed complete regression of sclerotic plaques. | [12]/M.A. de Rie |
| Plaque or generalized type LS | 14 | 5 s/w for 8 w | 20 | 40 | Skin status markedly improved in all 14 patients, resulting in a significant reduction of clinical score from baseline to the end of treatment. | [13]/A. Kreuter |
| Plaque or generalized type LS | 8 | 5 s/w for 8 w | 50 | 40 | Skin status markedly improved in all patients, resulting in a significant reduction of clinical score from baseline to the end of treatment. | [14]/Alexander Kreuter |
| Plaque, linear, generalized, deep or pansclerotic morphea. Generalized associated with LSA | 35 | 3-5 s/w for 10-15 w | 30 | 30-45 | In all patients, sclerotic plaques were softened and marked clinical improvement was observed in 29 of 35 patients. | [15]/Ozlem Su |
LS: localosed scleroderma, LSA: lichen sclerosusatrophicus, s/w: session per week, w: week.