Figure 3.

ChIV reversed isoflurane-induced decrease in hippocampal PSD-95 expressions in neonatal rats. The effects of isoflurane (1.8%, 6 h) and chIV (30 mg/kg, i.p.) on hippocampal protein expressions of PSD-95 (A), SNAP-25 (B) in neonatal rats were detected by Western blot analysis. (A) Isoflurane exposure induced a significant decrease in hippocampal protein expressions of PSD-95, whereas the decrease was reversed by the application of chIV. (B) Isoflurane exposure or combined treatment of chIV didn’t alter hippocampal protein levels of synapsin I in neonatal rats. Data were presented as mean ± SEM (n = 7 per group). *denotes p<0.05 when comparing the two groups under each end of the capped line.