Figure 3.

Inhibition of miR-205-5p reverses chemotherapeutic resistance in vivo. Hepatocellular carcinoma xenografts were established by injecting Bel/5-Fu cells into nude mice (A). The growth of tumor xenografts was slower in the combined 5-Fu+miR treatment group than in either the 5-Fu or miR groups alone (B). Tumor volume (C) and weight (D) are shown for each treatment group over time. The data are presented as the mean ± SD of three independent experiments. (NS: control group; 5-Fu: 5-Fu treatment group; miR: antagomiR-205-5p treatment group; 5-Fu+miR: co-treatment with 5-Fu and antagomiR-205-5p). *p<0.01, §p<0.05.