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. 2017 Sep 22;8:570. doi: 10.3389/fphar.2017.00570

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Copyright © 2017 Baselet, Azimzadeh, Erbeldinger, Bakshi, Dettmering, Janssen, Ktitareva, Lowe, Michaux, Quintens, Raj, Durante, Fournier, Benotmane, Baatout, Sonveaux, Tapio and Aerts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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X-ray irradiated ECs exhibit a persistent downregulation of caveolin-1, whereas Fe ion exposure induces a caveolin 1 upregulation. (A) Caveolin-1 (cav-1) and α-tubulin protein expression analyzed using western blot after cell exposure to a single 2.0 Gy dose fo X-ray or Fe ions. (B) Data represent the cav-1/α-tubulin ratio in control and irradiated samples after background correction and normalization to α-tubulin expression. Data show means ± SEM (N = 3, n = 12). ^*p < 0.05 using two-sided t-test (Welch-test).