Table 1.

X-ray irradiation of ECs induces an acute gene expression signature suggestive of cycle block and increased cellular adhesion.^*

	Upregulated description of process	−log10 (p-value)	Downregulated description of process	−log10 (p-value)
2 Gy X-rays Day 1	Regulation of multicellular organismal process	9	Cell cycle process	111
	Regulation of localization	9	Chromosome organization	76
	Signal transduction	9	DNA metabolic process	54
	Regulation of cellular component movement	8	Cell division	50
	Regulation of locomotion	8	DNA replication	44
	Cell adhesion	7	Cellular component organization or biogenesis	36
	Biological adhesion	7	Chromosome segregation	26
	Response to stimulus	7	Microtubule-based process	19
	Regulation of cell proliferation	7	Regulation of chromosome segregation	18
	Developmental process	7	DNA synthesis involved in DNA repair	18
2 Gy X-rays Day 7	Mitotic cell cycle process	14	Cell-substrate adhesion	7
	Cell division	10	Extracellular matrix organization	4
	Chromosome organization	9	Extracellular structure organization	4
	DNA replication initiation	9	Ethanol oxidation	4
	Cell proliferation	6	Biological adhesion	4
	Chromosome segregation	5	Post-embryonic organ morphogenesis	4
	Cellular component organization or biogenesis	5	Maintenance of location	3
	Regulation of chromosome segregation	5	Maintenance of protein location in extracellular region	3
	Negative regulation of blood coagulation	4
	Response to hypoxia	4

^*Gene ontology enrichment analysis was performed on differentially expressed genes in irradiated vs. sham-irradiated ECs (n = 3). Table shows the top 10 GO enrichment terms among upregulated (left) and downregulated (right) differentially expressed genes at day 1 (top) and at day 7 after 2 Gy of X-rays (bottom).