Table 2.

Fe ion irradiation of ECs induces a gene expression signature suggesting persistent cell cycle block and decreased cellular adhesion.^*

	Upregulated description of process	−log10 (p-value)	Downregulated description of process	−log10 (p-value)
2 Gy Fe ions Day 1	Signal transduction by p53 class mediator	11	Cell cycle process	99
	DNA damage response, signal transduction by p53 class mediator	7	Chromosome organization	67
	Positive regulation of cell cycle arrest	7	Cell division	49
	Response to radiation	7	DNA metabolic process	49
	Signal transduction in response to DNA damage	7	DNA replication	43
	Response to abiotic stimulus	7	Cellular component organization or biogenesis	38
	Regulation of cell proliferation	7	Chromosome segregation	26
	Regulation of apoptotic process	6	Microtubule-based process	19
	Response to stimulus	6	Regulation of chromosome segregation	18
	Chondroblast differentiation	5	Negative regulation of gene expression, epigenetic	17
2 Gy Fe ions Day 7	Developmental process	8	Regulation of endothelial cell migration	10
	Negative regulation of response to stimulus	8	Negative regulation of nucleic acid-templated transcription	10
	Regulation of locomotion	7	Regulation of signal transduction	9
	Regulation of cell proliferation	7	Developmental process	8
	Locomotion	7	Cytoskeleton organization	7
	Single-organism process	7	Response to endogenous stimulus	6
	Positive regulation of biological process	7	Regulation of cell death	6
	Single-organism developmental process	7	Regulation of cell cycle	6
	Regulation of multicellular organismal process	7	Regulation of cell proliferation	6
	Regulation of protein metabolic process	7	Cell adhesion	6

^*Gene ontology enrichment analysis (process) was performed on differentially expressed genes in irradiated vs. sham-irradiated ECs (n = 3). Table shows the top 10 GO enrichment terms among upregulated (left) and downregulated (right) differentially expressed genes on day 1 (top) or day 7 after 2 Gy of Fe ions (bottom).