Table 3.

Fe ions and X-ray irradiation induces protein expression involved in caveolar mediated endocytosis signaling and cell-cell adhesion, but at different time points.^*

	X-rays description of process	−log10 (p-value)	Fe ions description of process	−log10 (p-value)
Day 1	Caveolar-mediated Endocytosis Signaling	4.1	Remodeling of Epithelial Adherens Junctions	4.8
	RAN Signaling	2.9	tRNA Charging	4.5
	Glutathione Redox Reactions I	2.6	Glutathione-mediated Detoxification	3.5
	ILK Signaling	2.4	Integrin Signaling	3.3
	Virus Entry via Endocytic Pathways	2.4	Epithelial Adherens Junction Signaling	3.2
	Integrin Signaling	2.3	Mitochondrial Dysfunction	2.9
	Palmitate Biosynthesis I (Animals)	2.2	Germ Cell-Sertoli Cell Junction Signaling	2.9
	Uridine-5′-phosphate Biosynthesis	2.2	Oxidative Phosphorylation	2.8
	Fatty Acid Biosynthesis Initiation II	2.2	Paxillin Signaling	2.7
	Cell Cycle Control of Chromosomal Replication	2.2	EIF2 Signaling	2.7
Day 7	Remodeling of Epithelial Adherens Junctions	6.9	Caveolar-mediated Endocytosis Signaling	8.9
	Cell Cycle Control of Chromosomal Replication	5.1	Virus Entry via Endocytic Pathways	8.7
	Integrin Signaling	5.0	Neuroprotective Role of THOP1 in Alzheimer's Disease	6.5
	Epithelial Adherens Junction Signaling	5.0	Ephrin Receptor Signaling	5.5
	Gap Junction Signaling	4.6	Antigen Presentation Pathway	5.3
	Germ Cell-Sertoli Cell Junction Signaling	4.6	Phagosome maturation	5.2
	Sertoli Cell-Sertoli Cell Junction Signaling	4.5	NRF2-mediated Oxidative Stress Response	5.1
	Caveolar-mediated Endocytosis Signaling	4.0	Agrin Interactions at Neuromuscular Junction	5.1
	Death Receptor Signaling	3.6	Granzyme A Signaling	5.0
	Virus Entry via Endocytic Pathways	3.4	ERK/MAPK Signaling	5.0

^*Canonical pathway analysis was performed on differentially expressed proteins in irradiated vs. sham-irradiated ECs (n = 3). Table shows the top 10 molecular functions identified on day 1 (top) or day 7 (bottom) in ECs irradiated with 2 Gy of X-rays (left) or Fe ions (right).