Table 1.
Study summary of HIF-related effects through different physiological and biochemical pathways on breast cancer progression.
| HIF activity | Physiological Effects | Effects on cancer progression | |
|---|---|---|---|
| Denzel et al. (23) | ↓ | Reduced pulmonary metastasis | ↓ |
| Yao-Borengasser et al. (24) | ↓ | Reduction of ER gene expression | ↓ |
| Xiang et al. (25) | ↓ | Inhibition of HSP90 | ↓ |
| Liapis et al. (26) | ↓ | Evofosfamide binds to hypoxic bone cell | ↓ |
| Samanta et al. (27) | ↓ | Paclitaxel or gemcitabine alternate HIF expression in triple-negative breast cancers (TNBCs) | ↓ |
| Hardman et al. (28) | ↓ | Dietary with omega three fatty acids | ↓ |
| Wang et al. (29) | ↑ | Increase of microvesicles | ↑ |
| Chaturvedi et al. (30) | ↑ | Increased signaling between BCCs and mesenchymal stem cells (MSCs) | ↑ |
| Gehmert et al. (31) | ↑ | Hypoxia and inflammation lead to migration of MSCs | ↑ |
| Seifert et al. (32) | ↑ | TCDD inhibits ERα signaling in MCF7 cells | ↑ |
| Luo et al. (33) | ↑ | Reprogramming of glucose metabolism | ↑ |
| Siclari et al. (34) | ↑ | Encoding adrenomedullin | ↑ |
| Vaapil et al. (35) | ↑ | Promoting metastasis | ↑ |
| Pahlman et al. (36) | ↑ | Failed lactation in mammary epithelium | ↑ |
| Krutilina et al. (37) | ↑ | Increase of micRNA | ↑ |
| Martinez-Outschoorn et al. (38) | ↑ | Endorsed autophagy | ↑ |
| Milane et al. (39) | ↑ | Increased glycolysis | ↑ |
| Jones et al. (40) | ↑ | Moderate-intensity exercise | ↓ |