Table 1. Proteins involved in redox homeostasis.
| UniProt accession number | Description | Gene name | Average fold change upon siATM (nucleus) | Average fold change upon siATM (cytoplasm) |
|---|---|---|---|---|
| E9PQ63 | Carbonyl reductase [NADPH] 1 | CBR1 | 1.60 | 1.57 |
| P35754 | Glutaredoxin-1 | GLRXa | ND | 1.81 |
| Q86SX6 | Glutaredoxin-related protein 5, mitochondrial | GLRX5a | ND | 1.91 |
| P07203 | Glutathione peroxidase 1 | GPX1 | ND | 1.13 |
| E9PHN7 | Glutathione S-transferase Mu 2 | GSTM2 | ND | 1.47 |
| P21266 | Glutathione S-transferase Mu 3 | GSTM3 | ND | 1.43 |
| P78417 | Glutathione S-transferase omega-1 | GSTO1 | 1.21 | 1.21 |
| P09211 | Glutathione S-transferase P | GSTP1 | 1.25 | 1.25 |
| P09601 | Heme oxygenase 1 | HMOX1a | 1.69 | ND |
| B4DLR8 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 | 1.49 | 1.38 |
| Q06830 | Peroxiredoxin-1 | PRDX1a | 1.82 | 1.42 |
| P32119 | Peroxiredoxin-2 | PRDX2 | 1.31 | 1.04 |
| P30041 | Peroxiredoxin-6 | PRDX6 | 1.39 | 1.36 |
| P32322–2 | Pyrroline-5-carboxylate reductase 1, mitochondrial | PYCR1a | 1.24 | 1.56 |
| Q96C36 | Pyrroline-5-carboxylate reductase 2 | PYCR2 | 1.10 | 1.21 |
| Q9H3N1 | Thioredoxin-related transmembrane protein 1 | TMX1 | ND | 1.33 |
| Q9Y320–2 | Thioredoxin-related transmembrane protein 2 | TMX2 | 1.14 | ND |
| Q96JJ7 | Protein disulfide-isomerase TMX3 | TMX3a | 1.89 | 1.00 |
| Q86UY0 | Thioredoxin domain-containing protein 5 | TXNDC5 | 1.26 | 1.36 |
| O43396 | Thioredoxin-like protein 1 | TXNL1 | 1.49 | 1.21 |
| E9PIR7 | Thioredoxin reductase 1, cytoplasmic | TXNRD1a | 1.72 | 1.73 |
aStatistically significant hits from the SILAC analysis (Z-score > 2). The table reports the normalised siATM/siCtrl ratio obtained calculating the average of two technical replicates.
ND: not detected in the proteomics analysis.