Table 2. Proteins involved in the unfolded protein response and translation control.
| UniProt accession number | Description | Gene name | average fold change upon siATM (nucleus) | Average fold change upon siATM (cytoplasm) |
|---|---|---|---|---|
| O95817 | BAG family molecular chaperone regulator 3 | BAG3a | ND | 1.59 |
| Q16543 | Hsp90 co-chaperone Cdc37 | CDC37 | 1.44 | 1.34 |
| Q9UBS4 | DnaJ homolog subfamily B member 11 | DNAJB11 | 1.32 | 1.37 |
| Q9UDY4 | DnaJ homolog subfamily B member 4 | DNAJB4 | ND | 1.27 |
| X6R9L0 | DnaJ homolog subfamily C member 3 | DNAJC3 | 1.39 | 1.27 |
| P19525 | Interferon-induced, double-stranded RNA-activated protein kinase | EIF2AK2 | 1.26 | 1.20 |
| H0YME5 | Eukaryotic translation initiation factor 2-alpha kinase 4 | EIF2AK4 | 1.38 | ND |
| P38919 | Eukaryotic initiation factor 4A-II | EIF4A2a | 2.67 | 2.74 |
| Q9BS26 | Endoplasmic reticulum resident protein 44 | ERP44 | 1.52 | 1.28 |
| P08107 | Heat shock 70 kDa protein 1A | HSPA1A | 1.28 | 1.32 |
| P11021 | 78 kDa glucose-regulated protein | HSPA5 | 1.45 | 1.44 |
| P05161 | Ubiquitin-like protein ISG15 | ISG15a | ND | 1.81 |
| K7EJE8 | Lon protease homolog, mitochondrial | LONP1 | 1.41 | 0.86 |
| M0R208 | ATP-dependent Clp protease proteolytic subunit, mitochondrial | CLPP | ND | 1.24 |
aStatistically significant hits from the SILAC analysis (Z-score > 2). The table reports the normalised siATM/siCtrl ratio obtained calculating the average of two technical replicates.
ND: not detected in the proteomics analysis.