Fig. 1.

—(A) Distribution among human intergenic (IGR), near-genic (within 2 kb of transcription start or end sites), exonic, intronic and untranslated regions of ∼1.4 million microsatellites identified by Willems etal. (2014). Minimum length thresholds were 12 repeat copies for mononucleotide runs, 6 for dinucleotides and 4 for 3–6 bp repeat periods. (B) Distribution of microsatellites (periodicity 2–6 bp) with length variants showing significant effects on transcription (eSTRs) in lymphoblastoid cell lines (Gymrek etal. 2016).