Figure 2.

Model describing the progressive occurrence and accumulation of genetic alterations during the progression from non-dysplastic Barrett’s esophagus to invasive EAC, through the intermediate stages first of Barrett’s esophagus (BE) with low-grade dysplasia (LGD) and then BE with high-grade dysplasia (HGD). This model is based on results of studies reported by Weaver et al. [25] and Ross-Ines et al. [26].