Table 2.

Power calculations for continuous outcome measures

Outcome	Lowest clinically relevant difference	Expected standard deviation	Calculated power	Reference
Antipsychotic haloperidol equivalents	1.5	3	98%	Own unpublished data
Negative symptoms (negative dimension, based on mean of four global SANS scores)	0.4	1.2	75%	Petersen [45]
Cognition, overall score (BACS total)	15	42	80%	Melau [46]
Client satisfaction (CSQ)	2	5	88%	Petersen [45]
Social function (GSDS)	1.6	4.5	80%	Standard deviation based on [22]. Lowest clinically relevant difference is not known, but is set to Cohen’s d = 0.356, i.e.,low-to-moderate effect size

CSQ Patient Satisfaction Questionnaire, BACS Brief Assessment of Cognition in Schizophrenia, GSDS, Groningen Social Disabilities Schedule, SANS Schedule for Assessment of Negative Symptoms