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. 2017 Sep 29;8:206. doi: 10.1186/s13287-017-0655-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Structure of pMIGR1 vector and steps for UC-MSC transduction. a Structural construction of the bicistronic retroviral vector including both TRAIL and GFP sequences controlled by the IL-6 promoter. PIRES sequence was inserted to codify two different proteins from a single mRNA. b Sequential phases of multiple cell transfection, viral particle enrichment, and final transduction of UC-MSCs. GFP green fluorescent protein, MSC mesenchymal/stromal stem cell, pIL6 interleukin-6 promoter, PIRES poliovirus internal ribosome entry site, TRAIL tumor necrosis factor related apoptosis inducing ligand, UC umbilical cord