Fig. 7.

A proposed scheme of miR-524-5p regulation of the early stage of the reprogramming process [2, 3]. In the scheme, miR-524-5p promotes reprogramming by downregulating TP53INP1 to mediate processes associated with cell cycle, apoptosis, and expression of pluripotency genes, which are essential for the early stage of reprogramming. Furthermore, miR-524-5p also enhances MET, a required process for initial reprogramming, by targeting the EMT-related genes ZEB2 and SMAD4. See text for further description of the proposed scheme. EMT epithelial-to-mesenchymal transition, iPSC induced pluripotent stem cell, ROS reactive oxygen species