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. 2017 Sep 29;36:135. doi: 10.1186/s13046-017-0605-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of intranasal administrations of SFN, or of unprimed or SFN-primed MSCs on U87MG growth and angiogenesis. a Representation of the treatment protocol applied to U87MG-bearing mice. b Tumor volume distribution in each group, calculated by MRI on day 17. c Immunofluorescence staining for Ki67 and CD31 in the tumor on day 17 (scale bar = 100 μm). d and e Quantitative results for Ki67 and CD31 immunofluorescence. Results are expressed as the mean number of Ki67⁺ cells (d) or CD31⁺ vessels (e) per mm² ± SEM. (ǂp < 0.05, versus HBSS, SFN and SFN-primed MSCs; *p < 0.05, versus HBSS, SFN and unprimed MSCs)