Table 1.
Vaccine | Dose | No. of uninfected mice/total no. (%) |
---|---|---|
PBS | 4 | 0/10 (0) |
WT-AcNPV | 4 | 0/10 (0) |
BDES-PfCSP1-gp64 | 4 | 1/10 (10) |
BDES-sPfCSP2-Spier | 4 | 3/10 (30)a |
BDES-sPfCSP2-Spider | 4 | 6/10 (60)b |
Mice were screened for PfCSP-Tc/Pb blood-stage infections by microscopic examination of Giemsa-stained thin smears of tail blood after challenge infections. Protection is defined as the complete absence of blood-stage parasitemia on day 14 post-challenge
a, bEach group of immunized mice were compared with the nonimmunized group (PBS) to test for statistically significant differences using Fisher’s exact probability test. a p < 0.05; b p < 0.01