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. 2017 Sep 30;14:196. doi: 10.1186/s12974-017-0969-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Hepatic mRNA production of acute phase proteins and chemokines increases 8 days after LPS challenge in CR-EAE animals but not in CFA mice. Hepatic mRNA production of SAA1 (a), SAA2 (b), SAP (c) and CXCL-1 (d) was significantly higher in LPS-treated EAE mice (n = 5) when compared to that in saline-treated EAE mice (n = 5) (p < 0.05). No significant differences in CXCL-10 (e) and CCL5 (f) were found between the LPS-challenged mice and saline-treated animals. LPS administration in control CFA mice (n = 5) had no effect on the production of these acute phase proteins and chemokines when compared to saline-treated CFA mice (n = 4)