Table 1.
List of recent articles associating the outcomes of different types of bariatric surgery with single nucleotide polymorphisms (SNPs).
| Genes | Polymorphism | Main Results | Surgery/Time | N° Patients | Ref. |
|---|---|---|---|---|---|
| MC4R | rs17782313 | Women carrying this polymorphism present higher pre-surgical BMI and tend to maintain BMI > 35 kg/m2, which characterizes treatment failure | 60 months of RYGB | 217 | [21] |
| UCP2 | Ala55Val −866G > A |
Mutated alleles (T and A) could be biomarkers of weight loss | 12 months of RYGB | 150 | [22] |
| FTO | rs9930506 | Weight percentage is significantly higher in carriers of the AG and GG genotypes | Six months of sleeve gastrectomy | 11 | [28] |
|
PNPLA3 TM6SF2 MBOAT7 |
p.I148M p.E167E rs641738 |
Mutated allele might be associated with greater improvement of hepatic steatosis after bariatric surgery | One year of gastric bypass gastric sleeve | 84 | [29] |
| 5-HT2C | rs3813929 | The TT genotype predicts greater percentage of excess weight loss among female patients | 12 months of RYGB | 351 | [24] |
| FKBP5 | rs1360780 | The T allele is associated with weight loss. | Bariatric surgery | 42 | [25] |
| UCP2 | Ala55Val −866G > A |
Patients with at least one rare allele for polymorphisms and with at least one rare allele for both polymorphisms together (haplotype) present greater energy and carbohydrate intake even after adjustment for gender, age, and weight. | 12 months of RYGB | 150 | [30] |
| 32 SNPs | - | The LYPLAL1 genotype is associated with different eating behavior and loss of extensive body weight | Two years of RYGB | 251 | [31] |
| 330 SNPs | - | Information derived from patient DNA may be useful to predict surgical weight loss outcomes and to guide selection of surgical approach. | One year of RYGB or LAGB | 161 | [26] |
| FTO | rs9939609 | Weight loss progresses differently in obese carriers of the FTO gene variant rs9939609 after bariatric surgery | Two months of RYGB | 146 | [32] |
MC4R: melanocortin 4 receptor; UCP2: uncoupling protein 2; FTO: alpha-ketoglutarate-dependent dioxygenase or fat mass and obesity-associated protein; PNPLA3: patatin-like phospholipase domain containing 3; TM6SF2: transmembrane 6 superfamily member 2; MBOAT7: membrane-bound O-acyltransferase domain containing 7; 5-HT2C: 5-hydroxytryptamine receptor 2C; FKBP5: FK506 binding protein 5; n: number of individuals; RYGB: Roux-en-Y gastric by-pass; LAGB: laparoscopic adjustable gastric banding; BMI: body mass index.