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. 2017 Jul 4;102(10):1718–1726. doi: 10.3324/haematol.2017.171645

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Overview of the study design. RNA-sequencing was performed on rRNA-depleted total bone marrow of 40 cytogenetically normal acute myeloid leukemia (CN-AML) patients (Cohort 1) to determine the lncRNA transcriptome. A validation set composed of 134 new CN-AML patients (Cohort 2) was used to validate the results. Downregulation of XLOC_109948 lncRNA was performed in OCI-AML3 cells transfected with GapmeRs. sPLS-DA: Sparse partial least squares discriminant analysis.