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. 2017 Jul 4;102(10):1718–1726. doi: 10.3324/haematol.2017.171645

Figure 3.

Figure 3

A minimal set of 12 lncRNAs is able to discriminate between NPM1-mutated and NPM1-wild-type acute myeloid leukemia (AML) patients. (A) Sparse partial least squares discriminant analysis (sPLS-DA) plot of NPM1-mutated versus NPM1-wild-type patients based on 12 discriminating lncRNAs. (B) Variable plot of the 12 discriminative lncRNAs. (C) Hierarchical clustering of 40 cytogenetically normal acute myeloid leukemia (CN-AML) patients (Cohort 1) and associated heatmap of the 12 lncRNA signature identified by Sparse PLS-DA to compare NPM1-mutated (NPM1+) patients with NPM1-wild-type (NPM1wt) patients (Fluidigm data). (D) Hierarchical clustering of 134 CN-AML patients (Cohort 2: NPM1+, n=80; NPM1wt, n=54) and associated heatmap of the 12 lncRNA signature identified by Sparse-PLS-DA (Fluidigm data).