Table 1.

Laboratory findings in the three cases at admission

	Case 1	Case 2	Case 3
Age (years)	46	32	34
Sex	F	F	M
Creatinine (mg/dL)	2.2	2.15	2.97
Urea (g/L)	1.01	1.28
Urinalysis	No microhaematuria	No microhaematuria	Microhaematuria, glycosuria
24 h proteinuria (g)	1.5	4.9	1.32
Hb (g/dL)	6.9	8.0	6.3
Platelet (per mm3)	43 000	19 000	73 000
PT, APTT, antithrombin, D-dimer	Normal range	Normal range	Normal range
Lactate dehydrogenase (U/L)	1230	1929	1840
Coombs test	Negative	Negative	Negative
Haptoglobine	Undetectable	Undetectable	Undetectable
Schistocytes on peripheral blood smear (%)	7	5	3
ADAMTS-13 (%) (ref. 50 – 150%)	90	52	89
Anti-CFH antibodies	Negative	Negative	Negative
Complement gene mutation analysis	Negative (CFH, CFHR1-R3, MCP, CFI, CFB)	Non-pathogenic heterozygous deletion CFHR1-R3    (negative CFH, MCP, CFI and CFB)	Non-pathogenic heterozygous MCP mutation    (negative CFH, CFHR1-R3, CFI and CFB)

PT, prothrombin time; APTT, activated partial thromboplastin time.