Table 4.

Association of GRSs (as a continuous variable in SD units) with coronary events by disease state

GRS	GRS-1		GRS-2
Variables	HR (95% CI)	P-value	HR (95% CI)	P-value
Age and sex-adjusted
CKD 4/5	3.0 (1.71–5.26)	<0.001	2.05 (1.14–3.7)	0.017
Dialysis	1.03 (0.67–1.57)	0.899	0.92 (0.57–1.49)	0.739
Transplant	1.26 (0.88–1.8)	0.210	1.64 (1.10–2.45)	0.016
Transplant failure	0.88 (0.44–1.75)	0.711	1.12 (0.61–2.07)	0.713
Adjusted by estimated coronary risk according to the REGICOR function
CKD 4/5	2.86 (1.83–4.46)	<0.001	2.33 (1.38–3.92)	0.002
Dialysis	1.12 (0.66–1.92)	0.672	0.87 (0.49–1.52)	0.618
Transplant	1.17 (0.88–1.58)	0.315	1.43 (1.03–1.99)	0.033
Transplant failure	0.90 (0.42–1.91)	0.779	1.23 (0.63–2.43)	0.544

For GRS composition, see Supplementary Table S1.