Table 1.
Demographic and clinical characteristics of included ENCORE trial participants by eGFR
| All (n=139) | Normal-high kidney function eGFR ≥90 (n=74) | Mildly decreased kidney function eGFR 60–89 (n=65) | P-value | |
|---|---|---|---|---|
| Age, years | 52.0 (9.6) | 47.9 (7.0) | 56.3 (10.2) | <0.001 |
| Female gender, n (%) | 94 (65) | 56 (79) | 32 (46) | 0.001 |
| Race, n (%) | ||||
| White | 86 (60) | 40 (54) | 46 (66) | |
| Black | 56 (39) | 32 (43) | 24 (34) | |
| Asian | 2 (1) | 2 (3) | 0 (0) | 0.21 |
| Years of education | 15.2 (2.6) | 15.3 (2.5) | 15.0 (2.7) | 0.42 |
| Annual household income, n (%) | ||||
| <$25 000 | 21 (17) | 13 (21) | 8 (13) | |
| $25 000–50 000 | 31 (25) | 17 (27) | 14 (23) | |
| $50 000–100 000 | 44 (36) | 21 (33) | 23 (38) | |
| ≥$100 000 | 27 (22) | 12 (19) | 15 (25) | 0.28 |
| Weight, kg | 94.0 (14.1) | 94.2 (14.7) | 93.9 (13.6) | 0.84 |
| BMI, kg/m2 | 33.2 (3.9) | 33.9 (4.1) | 32.3 (3.5) | 0.01 |
| BP, mmHg | ||||
| Clinic SBP | 137.7 (8.8) | 136.5 (8.1) | 139.0 (9.3) | 0.08 |
| Clinic DBP | 85.5 (6.4) | 87.0 (5.9) | 84.0 (6.5) | <0.01 |
| Serum creatinine, mg/dL | 0.94 (0.17) | 0.85 (0.12) | 1.04 (0.16) | <0.01 |
| eGFR, mL/min/m2 | 89.1 (15.0) | 99.9 (9.5) | 77.3 (9.6) | <0.001 |
| Fasting cholesterol, mg/dL | 205 (40) | 206 (41) | 204 (38) | 0.80 |
| LDL cholesterol | 126 (36) | 125 (36) | 127 (35) | 0.83 |
| HDL cholesterol | 54 (14) | 55 (15) | 53 (14) | 0.32 |
| LDL/HDL ratio | 2.45 (0.93) | 2.37 (0.87) | 2.54 (1.0) | 0.27 |
| Stumvoll ISI, µmol/kg/min/pM | 0.089 (0.017) | 0.086 (0.017) | 0.092 (0.016) | 0.05 |
| Current smoker, % | 12 (9) | 7 (9) | 5 (8) | 0.71 |
| ASCVD risk, % | 5.0 (5.4)a | 2.7 (2.7) | 7.6 (6.5)a | <0.001a |
| IMT mm | 0.70 (0.15) | 0.66 (0.11) | 0.74 (0.17) | <0.01 |
| FMD % dilated | 2.9 (4.0) | 3.7 (4.5) | 2.0 (3.2) | 0.03 |
Values indicate mean (SD) unless otherwise indicated.
LDL, low-density lipoprotein; HDL, high-density lipoprotein; ISI, insulin sensitivity index.
a
For ASCVD risk analysis, total group N = 134 and mildly decreased kidney function group N = 65 after excluding five participants with age <40 or >79 years.