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Effects of H2S on insulin secretion by beta cells. (A) Insulin secretion is stimulated at high glucose levels and (B) inhibited at high H2S or low glucose levels. GLUT2, glucose transporter type 2; G, glucose; G-6-P, glucose 6-phosphate; MITO, mitochondria; ○, targets of H2S; ⊕, to activate; Θ, to inhibit.
