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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Sep 8;27(20):4687–4693. doi: 10.1016/j.bmcl.2017.09.011

Fig. 1.

Fig. 1

Structures and synthetic pathway of the compounds utilized in this study. Reagents and Conditions: (a) ZnCl2, POCl3, 70 °C, 3 hours, 69% yield; (b) epichlorohydrin, K2CO3, DMF, 80 °C, 5 hours, mw, 32% yield; (c) DMF, 50 °C, 26 hours, 32-80% yield; (d) CF3COOH, CH2Cl2, 0 °C, 2 hours or HCl in dioxane, 0 °C, 2-5 hours, 33-60%yield. Boc = (CH3)3COCO. * = hydrochloride salt; ** = trifluoroacetate salt.