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. Author manuscript; available in PMC: 2018 Oct 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Sep 8;27(20):4687–4693. doi: 10.1016/j.bmcl.2017.09.011

Fig. 11.

Fig. 11

Molecular modeling of compound 4. Docking of compound 4 into the DNA cleavage/ligation active site of topoisomerase IIα (Top). Superposition between etoposide (pdb: 3QX3) and the docking pose of compound 4 into the topoisomerase II DNA cleavage complex (Bottom).