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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2017 Sep 1;112:578–586. doi: 10.1016/j.freeradbiomed.2017.08.026

Figure 1.

Figure 1

Loss of Nrf2 potentiates radiation-induced tissue remodeling and collagen deposition. Male wild type (A, C, E, G) and Nrf2 null (B, D, F, H) mice were administered 0 (A, B, E, F) or 12 Gy (C, D, G, H) to the thorax and allowed to recover for 250 days. The degree of tissue remodeling was quantified from H&E sections (I, N = 112 fields, 10 mice) while collagen deposition was quantified from Masson’s trichrome staining (J, N = 71 fields, 10 mice). Black bar = 100 μm. Red arrow in panel C identifies tissue remodeling.