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. Author manuscript; available in PMC: 2018 Sep 20.
Published in final edited form as: Horm Behav. 2017 Sep 20;95:65–75. doi: 10.1016/j.yhbeh.2017.07.015

Figure 1.

Figure 1

Estrous status and effect of Intra-VTA THIP on ethanol intake. A) Following recovery from surgery, mice consumed an average of 2.75g/kg ethanol. B) THIP microinjection (50ng/200uL/side or 100ng/mouse) into the Posterior or Anterior VTA on day 7 significantly increased locomotion (*p’s<0.05). C) Intra-anterior VTA THIP at that same dose was not associated with a change in binge drinking. D)Intra-posterior VTA THIP at that dose was associated with an attenuation of binge drinking for non-estrus females only (*p<0.05, as compared to vehicle, #p<0.05, as compared to similarly treated estrus females; n’s=5–10/estrous status/region/dose).