Table 4.
Percent differencea in relative telomere length by serum polychlorinated biphenyls (PCBs), ACHS participants
White | African American | |||||
---|---|---|---|---|---|---|
|
|
|||||
%Difference | 95% CI | %Difference | 95% CI | |||
PCB 99 | ||||||
Per doubling of exposure | 1.65 | 0.36 | 2.94 | −0.05 | −1.17 | 1.08 |
<29.15 ppt | Referent | Referent | ||||
29.15–71.60 ppt | 2.31 | −2.13 | 6.97 | −2.42 | −8.74 | 4.32 |
71.60–189.60 ppt | 4.67 | −0.40 | 9.99 | 2.22 | −4.68 | 9.63 |
>189.60 ppt | 8.84 | 1.77 | 16.41 | −0.49 | −7.20 | 6.71 |
p for trend | 0.01 | 0.90 | ||||
p for quadratic | 0.69 | 0.64 | ||||
| ||||||
PCB 105 | ||||||
Per doubling of exposure | 1.77 | 0.40 | 3.15 | 0.18 | −0.57 | 0.93 |
<7.75 ppt | Referent | Referent | ||||
7.75–19.10 ppt | 2.01 | −2.43 | 6.66 | 1.30 | −4.14 | 7.05 |
19.10–58.20 ppt | 3.46 | −1.84 | 9.03 | 7.15 | 1.55 | 13.05 |
>58.20 ppt | 10.45 | 3.50 | 17.87 | 1.01 | −4.12 | 6.41 |
p for trend | 0.01 | 0.52 | ||||
p for quadratic | 0.25 | 0.03 | ||||
| ||||||
PCB 118 | ||||||
Per doubling of exposure | 1.87 | 0.55 | 3.21 | 0.02 | −1.07 | 1.12 |
<49.60 ppt | Referent | Referent | ||||
49.60–121.60 ppt | 3.05 | −1.60 | 7.93 | −0.62 | −6.71 | 5.87 |
121.60–361.80 ppt | 4.70 | −0.69 | 10.38 | 6.05 | −0.65 | 13.21 |
>361.80 ppt | 9.88 | 2.76 | 17.49 | −0.24 | −6.89 | 6.88 |
p for trend | 0.01 | 0.88 | ||||
p for quadratic | 0.68 | 0.05 | ||||
| ||||||
PCB 153 | ||||||
Per doubling of exposure | 1.75 | 0.26 | 3.26 | −0.74 | −1.94 | 0.47 |
<278.75 ppt | Referent | Referent | ||||
278.75–564.95 ppt | 5.40 | 0.53 | 10.51 | 0.67 | −6.06 | 7.89 |
564.95–1398.50 ppt | 7.08 | 1.64 | 12.82 | 2.39 | −4.42 | 9.70 |
>1398.50 ppt | 7.62 | 0.57 | 15.15 | −1.64 | −8.26 | 5.46 |
p for trend | 0.02 | 0.40 | ||||
p for quadratic | 0.19 | 0.15 | ||||
| ||||||
PCB 167 | ||||||
Per doubling of exposure | 1.33 | −0.20 | 2.89 | −0.02 | −1.20 | 1.17 |
<10.88 ppt | Referent | Referent | ||||
10.88–22.55 ppt | 2.08 | −3.00 | 7.43 | 1.87 | −5.52 | 9.83 |
22.55–57.20 ppt | 3.82 | −1.65 | 9.58 | 1.73 | −5.27 | 9.24 |
>57.20 ppt | 8.58 | 1.54 | 16.10 | −0.50 | −7.45 | 6.98 |
p for trend | 0.02 | 0.63 | ||||
p for quadratic | 0.57 | 0.33 | ||||
| ||||||
PCB 183 | ||||||
Per doubling of exposure | 1.60 | 0.05 | 3.17 | −0.13 | −1.34 | 1.09 |
<18.65 ppt | Referent | Referent | ||||
18.65–39.25 ppt | 2.59 | −2.12 | 7.53 | −0.53 | −7.08 | 6.49 |
39.25–93.40 ppt | 5.79 | 0.42 | 11.45 | 3.08 | −3.74 | 10.37 |
>93.40 ppt | 6.24 | −0.80 | 13.79 | 0.43 | −6.36 | 7.72 |
p for trend | 0.03 | 0.83 | ||||
p for quadratic | 0.63 | 0.40 | ||||
| ||||||
PCB 187 | ||||||
Per doubling of exposure | 1.22 | −0.19 | 2.64 | −0.26 | −1.42 | 0.92 |
<68.65 ppt | Referent | Referent | ||||
68.65–159.50 ppt | 5.56 | 0.42 | 10.95 | 2.52 | −4.62 | 10.20 |
159.50–394.75 ppt | 7.67 | 1.96 | 13.70 | 4.38 | −3.07 | 12.40 |
>394.75 ppt | 6.01 | −0.98 | 13.49 | 0.73 | −6.65 | 8.70 |
p for trend | 0.04 | 0.73 | ||||
p for quadratic | 0.07 | 0.09 | ||||
| ||||||
PCB 196 | ||||||
Per doubling of exposure | 1.21 | −0.43 | 2.87 | −0.24 | −1.57 | 1.10 |
<47.00 ppt | Referent | Referent | ||||
47.00–110.85 ppt | 6.30 | 0.53 | 12.40 | 0.45 | −6.38 | 7.78 |
110.85–249.35 ppt | 8.59 | 2.02 | 15.59 | −1.35 | −8.59 | 6.46 |
>249.35 ppt | 9.23 | 1.32 | 17.76 | −0.96 | −8.11 | 6.73 |
p for trend | 0.02 | 0.67 | ||||
p for quadratic | 0.16 | 0.93 | ||||
| ||||||
PCB 199 | ||||||
Per doubling of exposure | 0.51 | −0.96 | 1.99 | −0.60 | −1.82 | 0.65 |
<51.75 ppt | Referent | Referent | ||||
51.75–132.10 ppt | 4.98 | −0.78 | 11.07 | −3.28 | −9.85 | 3.77 |
132.10–318.30 ppt | 7.65 | 0.92 | 14.83 | −4.34 | −11.13 | 2.96 |
>318.30 ppt | 2.45 | −4.78 | 10.23 | −3.63 | −10.50 | 3.76 |
p for trend | 0.55 | 0.49 | ||||
p for quadratic | 0.01 | 0.33 |
Adjusted for age in years, age in years squared, total lipids, plate, smoking status, diabetes, education, sex, alcohol use in the past 30 days, and body mass index.