Annual regional poison center human exposure calls related to marijuana from January 1, 2000 through December 31, 2015, divided by age groups. *Counts significantly increased from previous year with a p value <0.003. †Unknown age includes calls with ages recorded as teens, 20s, unknown adult (≥20 yrs), unknown child (≤19 yrs), and unknown age. ‡Human marijuana exposure calls to RPC were determined by the presence of the generic code Marijuana - 0083000 from the National Poison Data System or marijuana exposure mentioned in RPC case notes.