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. Author manuscript; available in PMC: 2018 Mar 11.
Published in final edited form as: Lab Invest. 2017 Sep 11;97(10):1218–1224. doi: 10.1038/labinvest.2017.85

Table 1.

NSG embryo injection data by CRISPR/Cas9 dose.

Dose Injected Implanted Pups %Viability Blistered Non-
blistered		 %KO
Low 188 144 35 24% 12 23 34%
Med 303 231 39 16% 27 12 69%
High 505 348 79 22% 66 13 83%
High (B6) 215 130 36 27% 27 9 75%