Table 3.

Lipid and lipoprotein profiles by PNPLA3 and TM6SF2 genotypes

Genotype group	1	2	3	4	5	6	7
PNPLA3 I148M (rs738409)	−/− (CC)	−/+ (CG)	+/+ (GG)	−/− (CC)	−/+ (CG)	+/+ (GG)	−/+ (CG)
TM6SF2 E167K (rs58542926)	−/− (CC)	−/− (CC)	−/− (CC)	−/+ (CT)	−/+ (CT)	−/+ (CT)	+/+ (TT)
n (%)	48 (28%)	56 (32%)	31 (19%)	15 (9%)	13 (7%)	5 (3%)	2 (1%)
Conventional lipid profile 1 (mg/dL)
Triglyceride	205 ± 162	210 ± 102	185 ± 121	177 ± 85	142 ± 65	208 ± 156	558
Total cholesterol	192 ± 56	197 ± 34	202 ± 47	187 ± 53	168 ± 45	168 ± 42	195
LDL-C	108 ± 45	117 ± 29	118 ± 40	104 ± 51	97 ± 37	85 ± 53	98
HDL-C	48 ± 17	43 ± 11	47 ± 16	48 ± 10	42 ± 13	48 ± 9	26
Comprehensive lipoprotein profile VLDL concentration (nmol/L)
Total	81 ± 54	87 ± 47	72 ± 46	58 ± 28	61 ± 36	99 ± 70	92 ± 78
Large VLDL	11 ± 11	10 ± 7	9 ± 11	9 ± 8	8 ± 6	7 ± 7	19 ± 17
Medium VLDL	41 ± 28	45 ± 21	37 ± 24	28 ± 16	29 ± 16	50 ± 41	43 ± 38
Small VLDL	29 ± 25	32 ± 29	26 ± 20	21 ± 14	24 ± 18	43 ± 24	30 ± 22
IDL & LDL concentration (nmol/L)
Total	1487 ± 541	1497 ± 503	1448 ± 451	1335 ± 717	1355 ± 543	1062 ± 432	1294 ± 707
IDL	88 ± 81	110 ± 89	80 ± 55	93 ± 62	99 ± 57	72 ± 31	14 ± 1
Large LDL	403 ± 279	432 ± 309	517 ± 285	538 ± 359	439 ± 347	353 ± 261	77 ± 15
Small LDL	996 ± 478	955 ± 453	850 ± 388	704 ± 545	817 ± 393	637 ± 335	1204 ± 691
HDL concentration (µmol/L)
Total	36.6 ± 8.3	36.7 ± 6.7	36.5 ± 8.6	38.4 ± 5.8	36.2 ± 10.2	41.6 ± 10.1	30.1 ± 6.2
Large HDL	3.5 ± 2.4	3.6 ± 2.8	4.5 ± 4.8	4.7 ± 4.2	5.3 ± 3.8	6.9 ± 1.5	2.8 ± 3.2
Medium HDL	11.5 ± 5.7	12.0 ± 5.2	13.2 ± 5.5	11.2 ± 5.0	10.4 ± 7.2	14.5 ± 5.9	9.4 ± 5.4
Small HDL	8.9 ± 0.4	9.0 ± 0.5	9.1 ± 0.5	9.2 ± 0.5	9.2 ± 0.7	9.5 ± 0.3	8.7 ± 0.7
Lipoprotein particle size (nm)
VLDL3	56.4 ± 6.9	55.4 ± 6.9	54.2 ± 7.3	56.9 ± 10.1	56.5 ± 7.4	48.9 ± 4.3	64.4 ± 4.0
IDL and LDL	20.6 ± 0.9	20.7 ± 0.8	21.0 ± 0.7	21.3 ± 0.9	20.8 ± 1.0	21.1 ± 0.8	19.7 ± 0.1
HDL	8.9 ± 0.4	9.0 ± 0.5	9.1 ± 0.5	9.2 ± 0.5	9.2 ± 0.7	9.5 ± 0.3	8.7 ± 0.7

¹Only fasting subjects had measurements on conventional lipid profile