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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Haemophilia. 2017 May 5;23(5):759–768. doi: 10.1111/hae.13259

Figure 1. Comparison of 1–3% clotting factor activity patients against healthy donor response to TFlow or TFhigh bearing collagen surfaces.

Figure 1

(A & B), Platelet adherence and fibrin deposition dynamics measured by platelet and fibrin fluorescence respectively. WB inhibited with 40 μg/ml CTI was perfused over TFlow bearing collagen surfaces at 100 s−1. (B & C), Platelet adherence and fibrin deposition dynamics over time. WB inhibited with 40 μg/ml CTI was perfused over TFhigh bearing collagen surfaces at 100 s−1. Lines with shaded traces and points are the mean and standard deviation of 6 clotting events measured in 60 sec intervals over 15 min for three distinct hemophilic patients (red) or 18 clotting events measured in 60 sec intervals over 15 min for seven distinct healthy subjects (black). Aggregate hemophilic data was from one severely VIII-deficient patient (#62:3% factor level), one severely factor IX-deficient patient (#29:<1% factor level), and one moderately FVIII-deficient patient (#69:2% factor level). (** p < 0.01, * p < 0.05, ns: non-significant)