Table 5.

Descriptive statistics and analysis of child laboratory outcomes at 36 months by treatment group, with adjusted and unadjusted models (n=1017)

Laboratory outcomes	Values 32 weeks gestation*	Values 36 months*	Unadjusted model effect† (95% CI)	Adjusted model effect†‡ (95% CI)
Haemoglobin (g/dL)
Daily IFA	12.4 [1.2]	11.7 [0.9]	Reference	Reference
Twice-weekly IFA	12.4 [1.2]	11.7 [0.9]	0.05 (–0.10 to 0.19)	0.09 (–0.06 to 0.25)
Twice-weekly MMN	12.3 [1.2]	11.7 [1.0]	0.01 (–0.21 to 0.22)	0.01 (–0.20 to 0.22)
Anaemia (Hb<11.0 g/dL)
Daily IFA	35/344 (10.2)	58 (18.1)	Reference	Reference
Twice-weekly IFA	33/361 (9.1)	62 (18.5)	1.03 (0.69 to 1.53)	1.02 (0.67 to 1.56)
Twice-weekly MMN	42/318 (13.2)	60 (19.3)	1.08 (0.65 to 1.80)	1.08 (0.65 to 1.79)
Ferritin (μg/L)‡
Daily IFA	32 {24 to 55}	35{21 to 55}	Reference	Reference
Twice-weekly IFA	26 {18 to 37}	35 {21 to 52}	0.08 (–0.07 to 0.22)	0.07 (–0.08 to 0.22)
Twice-weekly MMN	21 {14 to 34}	35.5 {20 to 53.5}	0.01 (–0.15 to 0.18)	0.01 (–0.25 to 0.18)
Iron deficiency (ferritin<12 μg/L)
Daily IFA	3/342 (0.9)	12 (4.3)	Reference	Reference
Twice-weekly IFA	8/361 (2.2)	10 (3.4)	0.79 (0.31 to 2.04)	0.92 (0.35 to 2.40)
Twice-weekly MMN	19/315 (6.0)	15 (5.6)	1.31 (0.63 to 2.71)	1.49 (0.65 to 3.41)
B12 (pmol/L)‡
Daily IFA	230.5 {184 to 279}	530 {405 to 678}	Reference	Reference
Twice-weekly IFA	229 {187 to 285}	512 {392 to 680}	−0.01 (–0.10 to 0.09)	-0.01 (-1.0 to 0.10)
Twice-weekly MMN	233 {187 to 287.5}	502 {405 to 650.5}	0.02 (–0.08 to 0.11)	0.02 (-0.07 to 0.11)

*Data are mean [SD], number (%) or median {25th to 75 centile}.

†Effect is difference in means for haemoglobin, ferritin and B12 and OR for anaemia and iron deficiency.

‡Log base 2 transformed for statistical analysis.

§Adjusted for maternal age, parity, maternal education, maternal body mass index, maternal pathology at 32 weeks and clustering.

IFA, iron-folic acid; MMN, multiple micronutrients.