Figure 2.

Forest plot and TSA of screening versus no screening for cardiac events outcome. (A) Forest plot for cardiac events. (B) TSA for a relative risk reduction of 40%. The continuous blue line represents the Z line (cumulative effect size), red dashed lines represent the harm, benefit, and futility boundaries, and the estimated optimal sample size adjusted to sample size and repeated analysis. The continuous black lines represent the conventional CIs. RR, relative risk; RRR, relative risk reduction; TSA, trial sequential analysis.