Table 4.

Hazard ratios for hypokalaemia in patients treated with YK preparations*

Risk factors	Univariable analysis		Multivariable analysis
	Hazard ratio (95% CI)	p Value	Hazard ratio (95% CI)	p Value
YK administration (not YKCH)	2.84 (1.37 to 5.87)	0.005	3.09 (1.41 to 6.80)	0.005
LPIDs co-administration	2.88 (1.89 to 4.38)	<0.001	2.74 (1.75 to 4.29)	<0.001
Hypoalbuminaemia†	2.95 (1.94 to 4.49)	<0.001	2.15 (1.36 to 3.38)	0.001
Fully-dosed amount	1.64 (1.05 to 2.55)	0.029	1.60 (1.01 to 2.55)	0.048
Female	1.36 (0.89 to 2.06)	0.153	1.32 (0.85 to 2.03)	0.215
Age	1.00 (0.99 to 1.02)	0.537	1.00 (0.99 to 1.02)	0.673
Serum potassium† (≥4.1 mEq/L)	0.36 (0.24 to 0.54)	<0.001	0.45 (0.29 to 0.70)	<0.001

*Cox proportional hazard model was used.

†Determined at baseline.

LPIDs, lower potassium-inducing drugs; YK, Yokukansan; YKCH, Yokukansan-ka-chimpihange.