Table 2.

Associations between imaging markers of CSVD and motor function of lower extremities.

CSVD imaging markers	Gait speed		Chair-stand
	β (SE)	p	β (SE)	p
Total WMH
Model 1	-0.106 (0.040)	0.007*	0.157 (0.038)	<0.0001**
Model 2	-0.098 (0.040)	0.014*	0.150 (0.038)	0.0001**
Model 3	-0.092 (0.040)	0.022*	0.153 (0.039)	<0.0001**
PVWMH
Model 1	-0.096 (0.040)	0.016*	0.183 (0.038)	<0.0001**
Model 2	-0.087 (0.040)	0.029*	0.176 (0.038)	<0.0001**
Model 3	-0.080 (0.040)	0.047*	0.180 (0.039)	<0.0001**
DWMH
Model 1	-0.076 (0.038)	0.045*	0.102 (0.037)	0.006**
Model 2	-0.069 (0.038)	0.069	0.100 (0.037)	0.007**
Model 3	-0.066 (0.038)	0.083	0.101 (0.037)	0.006**
Lacunes
Model 1	-0.061 (0.038)	0.110	0.061 (0.037)	0.101
Model 2	-0.058 (0.038)	0.130	0.062 (0.037)	0.096
Model 3	-0.047 (0.039)	0.229	0.067 (0.038)	0.080
CMBs
Model 1	0.008 (0.036)	0.826	0.057 (0.036)	0.107
Model 2	0.006 (0.037)	0.869	0.070 (0.036)	0.052
Model 3	0.009 (0.037)	0.806	0.069 (0.036)	0.058
PVS-WM
Model 1	-0.026 (0.037)	0.477	0.005 (0.036)	0.896
Model 2	-0.029 (0.036)	0.420	0.004 (0.036)	0.901
Model 3	-0.027 (0.037)	0.457	0.007 (0.036)	0.853
PVS-BG
Model 1	-0.041 (0.036)	0.257	-0.018 (0.036)	0.605
Model 2	-0.044 (0.036)	0.228	-0.020 (0.036)	0.582
Model 3	-0.049 (0.037)	0.182	-0.022 (0.036)	0.549
BPF
Model 1	0.065 (0.051)	0.204	-0.081 (0.050)	0.108
Model 2	0.056 (0.051)	0.273	-0.068 (0.050)	0.171
Model 3	0.061 (0.052)	0.238	-0.067 (0.050)	0.186

β, standardized β coefficient; CSVD, cerebral small vessel disease; WMH, white matter hyperintensities; CMBs, cerebral microbleeds; PVS-WM, dilated perivascular spaces in white matter; PVS-BG, dilated perivascular spaces in BG; BPF, brain parenchymal fraction. Model 1: adjustment for age, sex, and height. Model 2: additional adjustment for MMSE, education level (high school and above vs. below). Model 3: additional adjustment for vascular risk factors (hypertension, DM, hyperlipidemia, and smoking status). ^∗Uncorrected p < 0.05.^∗∗Surviving a false discovery rate (FDR)-corrected threshold of p(FDR) = 0.05.