Table 3.

Associations between imaging markers of CSVD and motor function of upper extremities.

CSVD imaging markers	Pronation–supination		Finger-tapping
	β (SE)	p	β (SE)	p
Total WMH
Model 1	0.173 (0.038)	<0.0001**	0.018 (0.038)	0.628
Model 2	0.154 (0.038)	<0.0001**	0.008 (0.038)	0.833
Model 3	0.155 (0.038)	<0.0001**	0.007 (0.039)	0.846
PVWMH
Model 1	0.180 (0.038)	<0.0001**	0.028 (0.038)	0.457
Model 2	0.160 (0.038)	<0.0001**	0.017 (0.038)	0.649
Model 3	0.163 (0.038)	<0.0001**	0.020 (0.039)	0.608
DWMH
Model 1	0.115 (0.037)	0.002**	0.039 (0.036)	0.280
Model 2	0.106 (0.036)	0.003**	0.032 (0.036)	0.376
Model 3	0.104 (0.036)	0.005**	0.029 (0.037)	0.430
Lacunes
Model 1	0.035 (0.037)	0.352	0.002 (0.037)	0.962
Model 2	0.035 (0.036)	0.341	0.001 (0.036)	0.984
Model 3	0.031 (0.038)	0.420	0.004 (0.038)	0.926
CMBs
Model 1	0.059 (0.036)	0.102	0.034 (0.035)	0.335
Model 2	0.066 (0.036)	0.065	0.025 (0.036)	0.485
Model 3	0.065 (0.036)	0.071	0.026 (0.036)	0.479
PVS-WM
Model 1	-0.014 (0.036)	0.692	-0.028 (0.035)	0.430
Model 2	-0.014 (0.035)	0.692	-0.024 (0.035)	0.490
Model 3	-0.023 (0.035)	0.511	-0.018 (0.035)	0.611
PVS-BG
Model 1	0.030 (0.036)	0.395	-0.013 (0.035)	0.708
Model 2	0.026 (0.035)	0.456	-0.012 (0.035)	0.742
Model 3	0.022 (0.036)	0.535	-0.017 (0.036)	0.627
BPF
Model 1	-0.141 (0.049)	0.004**	-0.120 (0.048)	0.013*
Model 2	-0.126 (0.048)	0.009**	-0.117 (0.048)	0.015*
Model 3	-0.125 (0.049)	0.011**	-0.123 (0.049)	0.012*

β, standardized β coefficient; CSVD, cerebral small vessel disease; WMH, white matter hyperintensities; CMBs, cerebral microbleeds; PVS-WM, dilated perivascular spaces in WM; PVS-BG, dilated perivascular spaces in BG; BPF, brain parenchymal fraction. Model 1: adjustment for age and sex. Model 2: additional adjustment for MMSE, education level (high school and above vs. below). Model 3: additional adjustment for vascular risk factors (hypertension, DM, hyperlipidemia, and smoking status). ^∗Uncorrected p < 0.05. ^∗∗Surviving a FDR-corrected threshold of p(FDR) = 0.05.