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. 2017 Sep 27;10:308. doi: 10.3389/fnmol.2017.00308

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Copyright © 2017 Zhu, Chen, Meng, Ju, Zhang, Wu, Guo and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of endogenous CRH knock down on the serum CRH, ACTH and CORT levels of rats at 1 day after hepatectomy. Representative bands (A) in primary hypothalamus neurons after culture with siRNAs (n = 3) and quantification of the CRH secretion level (B) from primary hypothalamus neurons (n = 6) ^$vs. scramble siRNA group (p < 0.05). The injection and decapitation time (C) of siRNA administration. (D) Blood CRH, ACTH and CORT levels among the control, hepatectomy, siRNA and siCRH groups. The data are presented as the mean ± SD (n = 5) *vs. control group (p < 0.05); ^#vs. hepatectomy group (p < 0.05).