Table 3.
Multivariable analysis of laryngectomy‐free survival
| Variable | No. patients | No. events | T classification model | Continuous T‐MTV model | Dichotomized T‐MTV model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | HR | 95% CI | P‐value | |||
| Primary site | |||||||||||
| Larynx | 35 | 13 | Reference | Reference | Reference | ||||||
| Hypopharynx | 50 | 31 | 1.45 | 0.74–3.00 | 0.27 | 1.34 | 0.67–2.79 | 0.40 | 1.15 | 0.55–2.48 | 0.70 |
| Nodal status | |||||||||||
| Negative | 26 | 10 | Reference | Reference | Reference | ||||||
| Positive | 59 | 34 | 1.66 | 0.81–3.71 | 0.16 | 1.46 | 0.71–3.25 | 0.30 | 1.34 | 0.62–3.08 | 0.45 |
| T classification | |||||||||||
| T2‐T3 | 68 | 31 | Reference | ||||||||
| T4a | 17 | 13 | 2.43 | 1.20–4.68 | 0.01 | ||||||
| T‐MTV | |||||||||||
| per 10‐mL increment | 1.27 | 1.05–1.50 | 0.008 | ||||||||
| T‐MTV (mL) | |||||||||||
| ≤28.7 | 68 | 29 | Reference | ||||||||
| >28.7 | 17 | 15 | 4.16 | 1.97–8.70 | 0.0003 | ||||||
| AIC: 332.8 | AIC: 332.8 | AIC: 325.4 | |||||||||
AIC, Akaike's information criterion; CI, confidence interval; HR, hazard ratio; T‐MTV, metabolic tumor volume of primary tumor.