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. 2017 Aug 29;11(10):1475–1492. doi: 10.1002/1878-0261.12116

Figure 4.

Figure 4

In vivo inhibition of HSF1 reduced the tumor burden and suppressed the invasion of pancreatic cancer. (A) Representative macroscopic images of PDAC in KPC mice treated with vehicle or KRIBB11. The white dotted line shows the pancreas. (B) Histology of tumors from KPC mice in groups as indicated. (C) Quantification of the tumor weight in mice treated with vehicle or KRIBB11. (D) Representative images showing gastric wall invasion, intestinal invasion, peritoneal invasion, and diaphragmatic invasion in KPC mice. (E) Table listing the incidence of invasion in the KPC mice that were treated with vehicle or KRIBB11. (F) HE staining showing that liver metastasis occurred in the mice treated with vehicle. (G) Table listing the incidence of distant metastasis in the KPC mice treated with vehicle or KRIBB11. (H) Kaplan–Meier survival analysis of KPC mice treated with vehicle or KRIBB11. Scale bars = 100 μm. *P < 0.05.