Table 2.

Clinical scores.

Disability, motor, and cognitive tests		Function	Patients scores at TP1	Patients scores at TP2	Controls scores at TP1	Patients vs controls for non-continuous scores
						TP1	TP2
BRB-N cognition	SRT-LTS	Verbal memory	62.5 ± 6.6 (−0.3)	66.1 ± 5 (0.21)	65.1 ± 6.8	N/A	N/A
	SRT-CLTR	Verbal memory	57.7 ± 10.4 (−0.14)	62.4 ± 9.6 (0.26)	60.1 ± 10	N/A	N/A
	SRT-recall	Verbal memory	11.2 ± 1.2 (−0.03)	11.7 ± 0.4 (0.11)	11.6 ± 0.9	N/A	N/A
	SRT-delayed recall	Verbal memory	8.1 ± 2.5 (0.11)	8.3 ± 2.5 (0.04)	8.4 ± 1.9	N/A	N/A
	SDMT	Attention	60.1 ± 17.4 (0.09)	57.4 ± 12 (0.04)	58.5 ± 12.6	N/A	N/A
	WLG	Execution	27.5 ± 5.6 (0.13)	27.4 ± 7 (0.17)	27.1 ± 7.4	N/A	N/A
	PASAT	Cognitive	75.6 ± 18.9 (−0.12)	46.3 ± 12.1 (−0.05)	49.3 ± 11.8	N/A	N/A
Mood and fatigue	HAD-A	Anxiety	6.7 ± 4.2	6.5 ± 3.6	5.2 ± 3.2	ns	ns
	HAD-D	Depression	3.1 ± 2.3	2.32 ± 2.12	1.35 ± 1.5	p = 0.005	p = 0.01
	FSMC Cognitive	Cognitive fatigue	23.7 ± 9	22.7 ± 9.6	16.9 ± 6	p = 0.01	p = 0.04
	FSMC Motor	Motor fatigue	23.2 ± 10.4	23 ± 9.1	14.8 ± 5.8	p = 0.02	p = 0.001
Disability and motor function	EDSS	General disability	1.6 ± 0.25 median: 1.5	1.7 ± 0.4	N/A	N/A	N/A
	TWT	Motor	0.2 ± 0.06 (−0.42)	0.3 ± 0.04 (0.63)	0.28 ± 0.04	N/A	N/A
	9HPT	Motor	0.05 ± 0.01 (−0.7)	0.05 ± 0.01 (−0.35)	0.06 ± 0.01	N/A	N/A

Data are presented as mean raw scores ± SD; z-scores for continuous variables in patients are reported in brackets.

BRB-N, brief repeatable battery of neuropsychological tests; SRT-CLTR, selective reminding test-consistent long-term retrieval; SRT-recall, selective reminding test-long-term storage; SRT-delayed recall, selective reminding test-delayed recall; SDMT, symbol digit modalities test; PASAT, paced auditory serial addition test at 3 s; WLG, word list generation; HAD-A, Hospital Anxiety and Depression Scale-Anxiety; HAD-D, Hospital Anxiety and Depression scale-Depression; FSMC, Fatigue Scale for Motor and Cognitive functions; EDSS, Expanded Disability Status Scale; TWT, Timed 25-Foot Walk; 9HPT, Nine-Hole Peg Test.