Table 4.

Longitudinal analysis results of patients.

Regions of interest	T1		T2		MTR
	p-Value	CI (95%)	p-Value	CI (95%)	p-Value	CI (95%)
Normal-appearing tissue
NAWM	n.s		0.002* (83.4, 82.6)	[0.4–1.3]	n.s
NAGM	n.s		n.s	N.A	n.s
DGMN
Thalamus	n.s		0.01* (89.2, 87.1)	[0.9–3.2]	n.s
Pallidum	0.04* (945, 935)	[3.6–15.3]	0.01* (64.7, 63.6)	[0.5–1.7]	n.s
Putamen	n.s		0.0004** (75.4, 74.2)	[0.7–1.6]	n.s
Caudate	n.s		n.s	N.A	n.s
Lesions (z-scores)
WM	2.2e−14*** (6.3, 5.8)	[0.7–0.9]	n.s		9.07e−03* (−1.4, −1.3)	[−0.2 to 0.06]
GM	n.s		n.s		n.s
Mixed	3e−03** (13.1, 12.2)	[0.3–1]	n.s		0.03* (−2.8, −2.4)	[−0.3 to 0.07]

*p < 0.05, **p < 0.001, ***p < 0.00001, corrected p-values are reported when significant. T1, T2, T2*, and MTR mean values and z-score in MS lesions at TP1 and TP2 are reported in brackets.

CI, confidence interval; HSD, Honest Significant Difference.