Skip to main content
. 2017 Jul 28;9(10):1379–1397. doi: 10.15252/emmm.201607376

Figure 1. FGFR1 L342S luciferase assays.

Figure 1

  • A, B
    Reporter activity of FGFR1 WT and L342S stimulated with increasing doses of FGF8 (A) and FGF21 (B). FGFR1 L342S severely affects FGF8 signaling, with a 28‐fold increase in EC50 (P < 0.001). L342S also impairs FGF21 signaling, with a 20% reduction in maximal response (P = 0.001). The experiments were repeated three times. Data were plotted as mean ± SEM. Maximal responses and EC50 of mutants were compared to WT by F‐test. WT, wild type; EV, empty vector.