UV lesion abundance (red) and C>T mutation frequency (blue) in malignant melanoma along the right arm of chromosome 13 at a 1‐Mb scale. UV lesions are quantified by measuring fold change (FC) of IP/input. Observed UV lesion abundance in IMR90 cells (A) and predicted UV lesion abundance in melanocytes, obtained by a Random Forest Regression using melanocyte chromatin marks (described in Fig
2D) and DNase I hypersensitivity as predictor variables (B).