Skip to main content
. 2017 Aug 16;36(19):2829–2843. doi: 10.15252/embj.201796717

Figure 6. UV lesion distribution in primary cells mirrors mutation rates in malignant melanoma.

Figure 6

  • A, B
    UV lesion abundance (red) and C>T mutation frequency (blue) in malignant melanoma along the right arm of chromosome 13 at a 1‐Mb scale. UV lesions are quantified by measuring fold change (FC) of IP/input. Observed UV lesion abundance in IMR90 cells (A) and predicted UV lesion abundance in melanocytes, obtained by a Random Forest Regression using melanocyte chromatin marks (described in Fig 2D) and DNase I hypersensitivity as predictor variables (B).
  • C
    Heatmap showing scaled signal (refer to Materials and Methods) of UV lesion, lamin B1, and C>T mutations along right arm of chromosome 13 at a 1‐Mb scale.
  • D–F
    Genome‐wide mutation frequency in melanoma compared to UV lesion abundance (D); predicted UV lesion abundance in melanocytes (E); and lamin B1 association (F). Y‐axes are truncated at the 99th percentile.