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. 2017 Sep 8;18(10):1837–1853. doi: 10.15252/embr.201744147

Figure 3. lncRNA‐PAGBC promotes the metastasis of GBC cells.

Figure 3

  1. Transwell migration (left) and invasion (right) assays of NOZ and GBC‐SD cells transfected with a lentivirus encoding a shRNA against lncRNA‐PAGBC. Scale bars represent 100 μm.
  2. Transwell migration (left) and invasion (right) assays of SGC‐996 and EH‐GB1 cells transfected with a lentivirus encoding lncRNA‐PAGBC. Scale bars represent 100 μm.
  3. Intrasplenic injection model was established using NOZ cells. Representative images of luciferase signals in the mice at 42 days after the intrasplenic injection of 2 × 106 cells of the indicated NOZ cell clones (left). Middle panel: Representative livers from mice from the left panel. Right panel: Haematoxylin and eosin‐stained images of liver tissues isolated from the mice shown on the left. Scale bars represent 500 μm. Black arrows indicate the metastatic tumour.
  4. A statistical plot of the average number of liver metastases in the intrasplenic injection model. The data are shown as the means ± SD, n = 8. **P < 0.01 (Student's t‐test)