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. 2017 Sep 4;6(9):e376. doi: 10.1038/oncsis.2017.75

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Loss of BRCA1 transcriptionally induces β-hCG expression in different breast cancer cells. (a) Immunoflourescence analysis of stable knockdown of BRCA1 in MDAMB-231 cells. (b) Relative Luciferase activity of CGB5 and CGB7 upon stable knockdown of BRCA1 in MDAMB-231. Stable clones of control shRNA transfected MDAMB-231 cells served as control. Relative luciferase units were expressed as percentage of control. (c) qRT-PCR analysis of CGB5 and CGB7 expression upon stable knockdown of BRCA1 in MDAMB-231. Expression was normalized to control shRNA transfected stable MDAMB-231. qRT-PCR analysis of CGB5 and CGB7 expression in (d) SUM149 (e) MX1 and (f) MCF7 upon silencing BRCA1. Expression was normalized to control siRNA transfected SUM149, MX1 and MCF7, respectively.