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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Endocr Relat Cancer. 2017 Aug 19;24(10):T195–T208. doi: 10.1530/ERC-17-0243

Figure 1.

Figure 1

A pathway depicting the alterations in p27 expression in MEN1 and/or MEN4 that lead to tumorigenesis. Menin, encoded by MEN1, regulates the expression of p27 by forming a transcriptional activation complex with methyltransferase (MLL2) and RNA polymerase II (Pol III). Menin inactivation (MEN1 mutation) leads to decreased p27 expression. Mutations in CDKN1B, either solely or with MEN1 as a second germline hit, leads to a greater decrease in expression of p27 protein, triggering neoplasia.